Affiliation:
1. Merck Sharp & Dohme Research Laboratories, Division of Merck & Co., Inc., Rahway, New Jersey
Abstract
The superiority of
d
-methionine over
l
-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of
dl
-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only
dl
-methionine-
dl
-sulfoxide and S-methyl-
l
-cysteine showed considerable methionine-replacing activity. Lysine and α-aminoadipic acid were inactive.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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