Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env-Reference-Cited by-同舟云学术

Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env

Published:2019-06 Issue:11 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Anand Sai Priya¹²,Grover Jonathan R.³,Tolbert William D.⁴,Prévost Jérémie¹⁵,Richard Jonathan¹,Ding Shilei¹⁵,Baril Sophie¹,Medjahed Halima¹,Evans David T.⁶⁷,Pazgier Marzena⁴,Mothes Walther³,Finzi Andrés¹²⁵

Affiliation:

1. Centre de Recherche du CHUM, Montreal, Quebec, Canada

2. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada

3. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA

4. Infectious Diseases Division, Department of Medicine of Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

5. Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada

6. Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA

7. Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, USA

Abstract

HIV-1 has evolved to acquire several strategies to limit the exposure of its envelope glycoproteins (Env) on the surface of infected cells. In this study, we show that antibody-induced Env internalization is conformation specific and reduces the susceptibility of infected cells to antibody-dependent cellular cytotoxicity (ADCC). Thus, a better understanding of this mechanism might help develop antibodies with improved capacities to mediate ADCC.

Funder

HHS | National Institutes of Health

Canada Research Chairs

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00293-19

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