Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14<sup>+</sup>Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines-Reference-Cited by-同舟云学术

Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14⁺Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines

Published:2022-07-27 Issue:14 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hoffman Huxley K.¹,Aguilar Rebekah S.¹,Clark Austin R.¹,Groves Nicholas S.¹,Pezeshkian Nairi¹,Bruns Merissa M.¹,van Engelenburg Schuyler B.¹^ORCID

Affiliation:

1. Molecular and Cellular Biophysics Program, Department of Biological Sciences, University of Denver, Denver, Colorado, USA

Abstract

HIV-1 envelope glycoprotein (Env) evades immune neutralization through many mechanisms. One immune evasion strategy may result from the internalization of excess surface-exposed Env to prevent antibody-dependent cellular cytotoxicity or neutralization.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00767-22

Reference106 articles.

1. Few and Far Between: How HIV May Be Evading Antibody Avidity

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3. Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity