Multicopy bla OXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii-Reference-Cited by-同舟云学术

Multicopy bla OXA-58 Gene as a Source of High-Level Resistance to Carbapenems in Acinetobacter baumannii

Published:2007-07 Issue:7 Volume:51 Page:2324-2328
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bertini Alessia¹,Poirel Laurent²,Bernabeu Sandrine²,Fortini Daniela¹,Villa Laura¹,Nordmann Patrice²,Carattoli Alessandra¹

Affiliation:

1. Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanitá, Rome Italy

2. Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Université Paris XI, K.-Bicêtre, France

Abstract

ABSTRACT The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla OXA-58 but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the bla OXA-58 gene showed genetic variability, with the presence in several isolates of multiple copies of the bla OXA-58 gene; this extra copy number was likely related to an IS 26 -mediated transposition or recombination process.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01502-06

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