Tissue-Specific Gene Expression during Productive Human Papillomavirus 16 Infection of Cervical, Foreskin, and Tonsil Epithelium

Author:

Chatterjee Sreejata1,Do Kang Sa1ORCID,Alam Samina1,Salzberg Anna C.2,Milici Janice1,van der Burg Sjoerd H.3,Freeman Willard4,Meyers Craig1

Affiliation:

1. Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA

2. Bioinformatics Core, Penn State College of Medicine, Hershey, Pennsylvania, USA

3. Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands

4. University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

Abstract

Although the high-risk human papillomavirus 16 infects anogenital and oropharyngeal sites, the cervical epithelium has a unique vulnerability to progression of cancer. Host responses during persistent infection and preneoplastic stages can shape the outcome of cancer progression in a tissue-dependent manner. Our study for the first time reports differential regulation of critical cellular functions and signaling pathways during productive HPV16 infection of cervical, foreskin, and tonsil tissues. While the virus induces hyperproliferation in infected cells, it downregulates epithelial differentiation, epidermal development, and innate immune responses, according to the tissue type. Modulation of these biological functions can determine virus fitness and pathogenesis and illuminate key cellular mechanisms that the virus employs to establish persistence and finally initiate disease progression.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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