Telavancin In Vitro Activity against a Collection of Methicillin-Resistant Staphylococcus aureus Isolates, Including Resistant Subsets, from the United States

Abstract

ABSTRACT Telavancin had MIC 50 , MIC 90 , and MIC 100 values of 0.03, 0.06, and 0.12 μg/ml, respectively, against methicillin-susceptible Staphylococcus aureus , methicillin-resistant S. aureus (MRSA), and non-multidrug-resistant (non-MDR) and MDR subsets. MRSA with elevated MIC values for vancomycin (2 to 4 μg/ml) or daptomycin (1 to 2 μg/ml) had telavancin MIC 50 (0.06 μg/ml) values 2-fold higher than those of isolates with lower MIC results (MIC 50 , 0.03 μg/ml). However, telavancin had MIC 90 and MIC 100 results of 0.06 and 0.12 μg/ml (100% susceptible), respectively, regardless of the MRSA subset.