Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia-Reference-Cited by-同舟云学术

Efficacy of Telavancin in Comparison to Linezolid in a Porcine Model of Severe Methicillin-Resistant Staphylococcus aureus Pneumonia

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Battaglini D.¹²³⁴,Motos A.¹⁵⁶⁴,Li Bassi G.¹⁵⁶⁴⁷,Yang H.¹⁶,Pagliara F.¹²³,Yang M.¹⁶⁴,Aguilera Xiol E.¹⁵⁶⁴,Meli A.¹⁸,Bobi J.¹⁶,Frigola G.⁹,Senussi T.¹²³,Idone F.¹¹⁰,Travierso C.¹⁸,Chiurazzi C.¹¹¹,Fernandez-Barat L.¹⁵⁶⁴,Rigol M.¹⁶,Ramirez J.⁹,Pelosi P.²³,Chiumello D.⁸,Antonelli M.¹⁰¹²,Nicolau D. P.¹³^ORCID,Bringue J.¹⁴,Artigas A.¹⁴,Guerrero L.¹¹⁵,Soy D.¹⁵,Torres A.¹⁵⁶⁴^ORCID

Affiliation:

1. Division of Animal Experimentation, Department of Pulmonology, Hospital Clínic, Barcelona, Spain

2. Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy

3. Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, Italy

4. University of Barcelona, Barcelona, Spain

5. Centro de Investigación en Red de Enfermedades Respiratorias, Madrid, Spain

6. Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

7. BITRECS, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain

8. University of Milan, Milan, Italy

9. Departamento de Anatomía Patológica, Hospital Clínic de Barcelona, Barcelona, Spain

10. Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

11. Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy

12. Università Cattolica del Sacro Cuore, Rome, Italy

13. Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

14. Department of Intensive Care Medicine, CIBER Enfermedades Respiratorias, Corporacion Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain

15. Division of Medicines, Pharmacy Service, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain

Abstract

Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezolid in a porcine model of severe MRSA pneumonia. In 18 mechanically ventilated pigs (32.11 ± 1.18 kg), 75 ml of 10 6 CFU/ml of MRSA was administered into each pulmonary lobe.

Funder

Theravance Biopharma US

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01009-20

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