Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin-Reference-Cited by-同舟云学术

Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin

Published:2007-03 Issue:3 Volume:75 Page:1517-1519
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Tilly Kit¹,Bestor Aaron¹,Jewett Mollie W.¹,Rosa Patricia¹

Affiliation:

1. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840

Abstract

ABSTRACT We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01725-06

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