Affiliation:
1. Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known β-lactam antibiotics. At a concentration of 25 μg/ml, azlocillin inhibited 74% of
Enterobacter
, 97% of
Proteus mirabilis
, 64% of
Citrobacter
, 91% of
Pseudomonas aeruginosa
, and 82% of
Bacteroides
strains tested. Mezlocillin inhibited 86% of
Shigella
, 96% of
Enterobacter
, 80% of indole-positive
Proteus
, 88% of
Bacteroides
, and 63% of
Pseudomonas
strains tested. Azlocillin was more active against
Pseudomonas
than was ticarcillin, carbenicillin, or mezlocillin. Mezlocillin was more active than carbenicillin and ampicillin against
Escherichia coli, Klebsiella, Enterobacter, Citrobacter, Acinetobacter, Serratia
, and
Bacteroides
. Azlocillin and mezlocillin were less active than cefazolin against β-lactamase-producing
E. coli
and
Klebsiella
strains but more active than cefazolin against
Enterobacter
, indole-positive
Proteus, Acinetobacter, Citrobacter
, and
Serratia
strains. Both compounds showed activity equivalent to that of cefoxitin against
Bacteroides
isolates. Both agents were destroyed by many of the β-lactamases from gram-negative organisms.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
131 articles.
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