Affiliation:
1. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Abstract
Netilmicin (Sch 20569) is an ethyl derivative of gentamicin C
1a
that is active against most
Enterobacteriaceae, Pseudomonas aeruginosa
, and
Staphylococcus aureus
isolates. Among 342 clinical isolates tested, all staphylococci; 92% of
Escherichia coli
, 93% of
Klebsiella pneumoniae
, and 92% of
Enterobacter
were inhibited by 0.8 μg or less of netilmicin per ml, but only 78% of
P. aeruginosa
were inhibited by 3.1 μg or less per ml. Most clinical isolates of enterococci,
Serratia marcescens
, and
Providencia
were not inhibited by 3.1 μg of netilmicin per ml. Like other aminoglycosides, the netilmicin in vitro activity was markedly influenced by the growth medium used, with activity decreased by sodium, calcium, and magnesium. Netilmicin was more active at alkaline pH. Addition of magnesium to
Pseudomonas
or
Serratia
pretreated with netilmicin produced inhibition of killing. Netilmicin was more active than gentamicin, sisomicin, tobramycin, or amikacin against
E. coli
and
K. pneumoniae
. Netilmicin inhibited growth of all gentamicin-resistant isolates of
Klebsiella
and
Citrobacter
tested, but only 73% of
E. coli; Pseudomonas
and
Providencia
were resistant to netilmicin. Most
Serratia
(95%) and indole-positive
Proteus
(83%) isolates were resistant to netilmicin but were inhibited by amikacin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
65 articles.
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