Affiliation:
1. Department of Immunology-Medical Microbiology, University of Florida College of Medicine, Gainesville, Florida 32601
2. Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32601
Abstract
Sisomicin is a new antibiotic produced by
Micromonospora inyoensis
. The in vitro activities of sisomicin, gentamicin, and tobramycin, three similar aminoglycosides, were determined against 228 clinical isolates representing 10 genera of common pathogens. No difference was noted in the activities of these antimicrobial agents when assayed by a standard broth dilution technique against
Klebsiella, Enterobacter, Escherichia, Salmonella, Citrobacter
, enterococci, or
Staphylococcus aureus
. Sisomicin was significantly more active than tobramycin against
Serratia
and indole-positive
Proteus
strains. Sisomicin was significantly more active than gentamicin against indole-negative
Proteus
strains and slightly more active against indole-positive
Proteus
strains. Tobramycin was more active than sisomicin or gentamicin against
Pseudomonas
and indole-negative
Proteus
strains. Gram-negative bacilli resistant to one of the three antimicrobial agents were not necessarily resistant to either of the other two. Activity of sisomicin was independent of the susceptibility or resistance of these isolates to nine other antimicrobial agents as assayed by the Bauer-Kirby technique. The presence of 50% human serum did not antagonize the in vitro activity of sisomicin against gram-negative isolates. Because sisomicin showed certain advantages over gentamicin or tobramycin in vitro, further investigation of this new antimicrobial agent is warranted.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference12 articles.
1. Numerical diagnostic key for the identification of;Baer H.;Enterobacteriaceae. Appl. Microbiol.,1972
2. Antibiotic susceptibility testing by a standardized single disc method;Bauer A. W.;Amer. J. Clin. Pathol.,1966
3. Preliminary studies with nebramycin factor 6;Black H. R.;Antimicrob. Ag. Chemother.,1971
4. Cross-resistance of Pseudomonas to gentamicin and tobramycin;Brusch J. L.;Antimicrob. Ag. Chemother.,1972
5. Is there complete cross-resistance of gram-negative bacilli to gentamicin and tobramycin;Crowe C. C.;Antimicrob. Ag. Chemother.,1972
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