Transactivation of Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 4 Enhancer by Glucocorticoid Receptor and Stress-Induced Transcription Factors Requires Overlapping Krüppel-Like Transcription Factor 4/Sp1 Binding Sites

Author:

Ostler Jeffery B.1,Thunuguntla Prasanth1,Hendrickson Bailey Y.1,Jones Clinton1ORCID

Affiliation:

1. Oklahoma State University College of Veterinary Medicine, Department of Veterinary Pathobiology, Stillwater, Oklahoma, USA

Abstract

Certain stressful stimuli activate the glucocorticoid receptor (GR) and increase the incidence of herpes simplex virus 1 (HSV-1) reactivation from latency. For example, a corticosteroid antagonist impairs productive infection and virus shedding following explant of trigeminal ganglia from latently infected mice.

Funder

HHS | National Institutes of Health

USDA | National Institute of Food and Agriculture

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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