In Vitro and In Vivo Coinfection and Superinfection Dynamics of Mayaro and Zika Viruses in Mosquito and Vertebrate Backgrounds

Author:

Brustolin Marco12,Pujhari Sujit13,Terradas Gerard1,Werling Kristine1,Asad Sultan1,Metz Hillery C.1,Henderson Cory A.1,Kim Donghun14,Rasgon Jason L.1ORCID

Affiliation:

1. Department of Entomology, the Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, the Pennsylvania State University, University Park, Pennsylvania, USA

2. Unit of Entomology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

3. Department of Pharmacology Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA

4. Department of Vector Entomology, Kyungpook National University, Daegu, South Korea

Abstract

Epidemiological and clinical studies indicate that multiple arboviruses are cocirculating in human populations, leading to some individuals carrying more than one arbovirus at the same time. In turn, mosquitoes can become infected with multiple pathogens simultaneously (coinfection) or sequentially (superinfection).

Funder

HHS | National Institutes of Health

U.S. Department of Agriculture

Dorothy Foehr Huck and J. Lloyd Huck Endowment

National Science Foundation

National Research Foundation of Korea

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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