New Complex Recombinant Genotype of Hepatitis B Virus Identified in Vietnam-Reference-Cited by-同舟云学术

New Complex Recombinant Genotype of Hepatitis B Virus Identified in Vietnam

Published:2008-06 Issue:11 Volume:82 Page:5657-5663
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Huy Tran Thien Tuan¹,Ngoc Trinh Thi²,Abe Kenji¹

Affiliation:

1. Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan

2. National Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam

Abstract

ABSTRACT A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel intergenotypic recombination between genotypes A, C, and G. VH24 showed high similarity (98.3 to 98.9%) to the “aberrant strains” among Vietnamese isolates reported by Hannoun et al. (C. Hannoun et al., J. Gen. Virol. 81:2267-2272, 2000) and also had similar breakpoints of recombination. Phylogenetic analysis of the complete genome of these strains formed a separate clade. Furthermore, their pre-S/S gene-encoded seven unique conserved amino acid residues were not present in other genotypes. These findings support the designation of the new genotype I.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02556-07

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