Nocardia africana sp. nov., a New Pathogen Isolated from Patients with Pulmonary Infections

Author:

Hamid Mohamed E.12,Maldonado Luis2,Sharaf Eldin Ghada S.3,Mohamed Maha F.3,Saeed Nageeb S.3,Goodfellow Michael2

Affiliation:

1. Department of Preventive Medicine and Public Health, Faculty of Veterinary Science, University of Khartoum, Khartoum North,1 and

2. Department of Agricultural and Environmental Science, University of Newcastle, Newcastle upon Tyne NE1 7RU, United Kingdom2

3. Tuberculosis Reference Laboratory, National Health Laboratory, Khartoum,3 Sudan, and

Abstract

ABSTRACT Eight actinomycete strains, isolated from 8 out of 400 sputum samples examined, taken from patients with pulmonary diseases at the Chest Unit of Khartoum Teaching Hospital in the Sudan, were provisionally assigned to the genus Nocardia according to morphological criteria. These isolates were studied further in order to establish their taxonomic status. They were found to have morphological and chemical properties typical of nocardiae and formed a monophyletic clade in the 16S ribosomal DNA tree together with Nocardia vaccinii . The strains showed a unique pattern of phenotypic properties that distinguished them from representatives of recognized Nocardia species, including Nocardia vaccinii . The strains were considered to merit species status and were designated Nocardia africana sp. nov. The findings of the present study are consistent with the view that pulmonary nocardiosis may occur in a substantial proportion of patients who exhibit chronic lung diseases in African countries. It is important, therefore, that clinicians in such countries consider this condition, especially when patients with respiratory infections fail to respond to antitubercular therapy.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference48 articles.

1. Nocardiosis: a neglected chronic lung disease in Africa?;Baily G. G.;Thorax,1988

2. Chun J. Computer-assisted classification and identification of actinomycetes. Ph.D. thesis. 1995 University of Newcastle Newcastle upon Tyne United Kingdom

3. A. phylogenetic analysis of the genus Nocardia with 16S rRNA gene sequences;Chun J.;Int. J. Syst. Bacteriol.,1995

4. Phylogeny of mycolic acid-containing actinomycetes;Chun J.;J. Ind. Microbiol.,1996

5. A. proposal to reclassify Nocardia pinensis Blackall et al. as Skermania piniformis gen. nov., comb. nov;Chun J.;Int. J. Syst. Bacteriol.,1997

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