Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models-Reference-Cited by-同舟云学术

Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models

Published:2017-07 Issue:7 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Christensen Luisa¹²,Turner Rob³,Weaver Sean³,Caserta Francesco³,Long Lisa¹²,Ghannoum Mahmoud¹²,Brown Marc³⁴

Affiliation:

1. Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA

2. University Hospitals Case Medical Center, Cleveland, Ohio, USA

3. MedPharm Ltd., Surrey Research Park, Guildford, United Kingdom

4. TDDT, School of Health and Life Sciences, University of Hertfordshire, Hatfield, United Kingdom

Abstract

ABSTRACT In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.

Funder

Humco

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02554-16

Reference6 articles.

1. Update on the Management of Onychomycosis: Highlights of the Third Annual International Summit on Cutaneous Antifungal Therapy

2. Topical Treatments for Onychomycosis

3. Effect of a novel penetration enhancer on the ungual permeation of two antifungal agents