Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Omollo Charles¹²³⁴,Singh Vinayak¹²³⁴^ORCID,Kigondu Elizabeth¹²³,Wasuna Antonina¹²³,Agarwal Pooja³⁴,Moosa Atica³⁴,Ioerger Thomas R.⁵,Mizrahi Valerie³⁴⁶,Chibale Kelly¹²⁴,Warner Digby F.³⁴⁶^ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch, South Africa

2. South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, South Africa

3. SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Rondebosch, South Africa

4. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa

5. Texas A&M University, Department of Computer Science, College Station, Texas, USA

6. Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Rondebosch, South Africa

Abstract

Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tuberculosis .

Funder

Novartis Research Foundation

Strategic Health Innovations Partnerships Unit of the South African Medical Research Council

Carnegie Mellon Scholarship Awards

Norges Forskningsråd

South African Medical Research Council

University of Cape Town

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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