Why Molnupiravir Fails in Hospitalized Patients-Reference-Cited by-同舟云学术

Why Molnupiravir Fails in Hospitalized Patients

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Brown Ashley N.¹²³,Lang Yinzhi⁴,Zhou Jieqiang⁴,Franco Evelyn J.¹³,Hanrahan Kaley C.¹²,Bulitta Juergen B.¹⁴^ORCID,Drusano George L.¹²^ORCID

Affiliation:

1. Institute for Therapeutic Innovation, University of Florida, Orlando, Florida, USA

2. Department of Medicine, College of Medicine, University of Florida, Orlando, Florida, USA

3. Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA

4. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA

Abstract

In this study, we showed that early intervention with molnupiravir resulted in a greater antiviral effect, and we explained the mechanism behind this phenomenon. Our results predicted and explained the failure of molnupiravir in hospitalized patients and highlighted the utility of preclinical pharmacodynamic studies to design optimal antiviral regimens for the treatment of viral diseases.

Funder

University of Florida Clinical and Translational Science Institute

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02916-22

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