Bistable Expression of a Toxin-Antitoxin System Located in a Cryptic Prophage of Escherichia coli O157:H7-Reference-Cited by-同舟云学术

Bistable Expression of a Toxin-Antitoxin System Located in a Cryptic Prophage of Escherichia coli O157:H7

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Jurėnas Dukas¹^ORCID,Fraikin Nathan¹^ORCID,Goormaghtigh Frédéric¹,De Bruyn Pieter²³,Vandervelde Alexandra²³,Zedek Safia¹,Jové Thomas⁴,Charlier Daniel⁵,Loris Remy²³,Van Melderen Laurence¹^ORCID

Affiliation:

1. Cellular and Molecular Microbiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Gosselies, Belgium

2. Structural Biology Brussels, Department of Bioengineering Sciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium

3. Molecular Recognition Unit, Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium

4. INSERM, CHU Limoges, RESINFIT, U1092, University of Limoges, Limoges, France

5. Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Abstract

Transcriptional regulation of bacterial toxin-antitoxin (TA) systems allows compensation of toxin and antitoxin proteins to maintain a neutral state and avoid cell intoxication unless TA genes are lost. Such models have been primarily studied in plasmids, but TAs are equally present in other mobile genetic elements, such as transposons and prophages.

Funder

FNRS

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02947-21

Reference71 articles.

1. Disorder- and Dynamics-Based Regulatory Mechanisms in Toxin–Antitoxin Modules

2. Toxin-antitoxin systems in bacterial growth arrest and persistence

3. Type II Toxin-Antitoxin Systems: Evolution and Revolutions