Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi-Reference-Cited by-同舟云学术

Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rudolph Michael J.¹,Davis Simon A.¹,Haque H. M. Emranul²,Weis David D.²,Vance David J.³,Piazza Carol Lyn³,Ejemel Monir⁴,Cavacini Lisa⁴,Wang Yang⁴,Mbow M. Lamine⁵,Gilmore Robert D.⁵^ORCID,Mantis Nicholas J.³^ORCID

Affiliation:

1. New York Structural Biology Center, New York, New York, USA

2. Department of Chemistry, University of Kansas, Lawrence, Kansas, USA

3. Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA

4. MassBiologics of the University of Massachusetts Chan Medical School, Boston, Massachusetts, USA

5. Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Abstract

The spirochete Borreliella burgdorferi is a causative agent of Lyme disease, the most common tickborne disease in the United States. The spirochete is transmitted to humans during the course of a tick taking a bloodmeal.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02981-22

Reference100 articles.

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2. Lyme borreliosis

3. Lyme Disease—a Tick-Borne Spirochetosis?

4. The Family Borreliaceae (Spirochaetales), a Diverse Group in Two Genera of Tick-Borne Spirochetes of Mammals, Birds, and Reptiles

5. Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion

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