Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp-Reference-Cited by-同舟云学术

Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp

Published:2005-08 Issue:8 Volume:43 Page:4168-4171
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Black Jennifer A.¹,Thomson Kenneth S.¹,Buynak John D.²,Pitout Johann D. D.³

Affiliation:

1. Center for Research in Anti-infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska

2. Southern Methodist University, Dallas, Texas

3. Division of Microbiology, Calgary Laboratory Services, and Departments of Pathology and Laboratory Medicine, Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

Abstract

ABSTRACT The diagnostic utility of the AmpC β-lactamase inhibitors LN-2-128, 48-1220, and Syn 2190 in combination with cefotetan (CTT) or cefoxitin in a disk test for the detection of clinical isolates of Klebsiella spp. producing plasmid-mediated AmpC β-lactamases (pAmpCs) was evaluated. The combination of Syn 2190 and CTT had a sensitivity of 91%, a specificity of 100%, and a reproducibility of 100% and showed the best potential of using an inhibitor for detection of Klebsiella spp. producing pAmpCs.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.8.4168-4171.2005

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