Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein-Reference-Cited by-同舟云学术

Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Yuqi¹,He Minjing¹,Gong Ruijie¹,Wang Ziteng¹,Lu Lin¹,Peng Shu¹,Duan Zhiyun¹,Feng Ying¹,Liu Yi²,Gao Bo¹^ORCID

Affiliation:

1. Department of Immunology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, and Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

2. Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

Abstract

HBV cccDNA is a determining factor for viral persistence and the main obstacle for a cure of chronic hepatitis B. Strategies that target cccDNA directly are therefore of great importance in controlling persistent HBV infection.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00546-22

Reference56 articles.

1. Hepatitis B Virus Infection

2. Chronic hepatitis B virus infection

3. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B