Affiliation:
1. Northern Regional Research Center, U.S. Department of Agriculture, Peoria, Illinois 61604.
Abstract
Liquid cultures of a mutant strain of Fusarium sporotrichioides NRRL 3299 that accumulates trichodiene rather than T-2 toxin converted tricho-9-ene-2 alpha,3 alpha,11 alpha-triol, trichotriol (tricho-10-ene-2 alpha,3 alpha,9 alpha-triol), tricho-10-ene-2 alpha,3 alpha,9 beta-triol, 3 alpha-hydroxytrichothecene, and 3 alpha-acetoxytrichothecene to T-2 toxin. Other possible oxygenated precursors of T-2 toxin, including trichodiol (tricho-10-ene-2 alpha,9 alpha-diol), trichothecene, 4 alpha-hydroxytrichothecene, and 15-hydroxytrichothecene, were not metabolized. The results indicate that in the biosynthesis of T-2 toxin by F. sporotrichioides, (i) oxygenation at C-3 occurs prior to the second cyclization, (ii) this second cyclization involves two steps that may be nonenzymatic, and (iii) oxidation at C-3 precedes that at C-4 or C-15.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Reference19 articles.
1. ApSimon J. W. B. Blackwell R. Greenhalgh R. M. Meier D. Miller J. R. J. Pare and A. Taylor. 1985. Secondary metabolites produced by some Fusarium species p. 125-136. In P. S. Steyn and R. Vleggaar (ed.) Mycotoxins and phycotoxins. Elsevier Science Publishing Inc. New York.
2. Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway. Appi;Bennett J. W.;Environ. Microbiol.,1980
3. Isolation and characterization of mutants blocked in T-2 toxin biosynthesis;Beremand M. N.;Appl. Environ. Microbiol.,1987
4. Mycotoxins-their biosynthesis in fungi: biosynthesis of the trichothecenes;Ciegler A.;J. Food Prot.,1979
5. Toxic trichothecenes from Fusarium sporotrichioides (MC72083);Corley D. G.;J. Org. Chem.,1987
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