Plasmodium Preerythrocytic Vaccine Antigens Enhance Sterile Protection in Mice Induced by Circumsporozoite Protein-Reference-Cited by-同舟云学术

Plasmodium Preerythrocytic Vaccine Antigens Enhance Sterile Protection in Mice Induced by Circumsporozoite Protein

Published:2021-10-15 Issue:11 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Daniel Shaji¹,Pichugin Alexander²,Torano Holly¹,Renn Jonathan P.¹,Kwan Jennifer³,Cowles Matthew V.¹,Conteh Solomon¹,Lambert Lynn E.¹,Alani Nada¹,MacDonald Nicholas J.¹,Dai Weili¹,Highsmith Kendrick¹,Anderson Charles¹,Gorres J. Patrick¹,Musgrove Javonn¹,Butler Brandi¹,Althubaiti Nouf²,Dixit Saurabh²,Zarling-Bejma Stasya²,Krzych Urszula²,Duffy Patrick E.¹^ORCID

Affiliation:

1. Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

2. Department of Cellular Immunology, Malaria Biologics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

3. Epidemiology Unit, Laboratory of Clinical Infectious Disease, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Preerythrocytic vaccines prevent malaria by targeting parasites in the clinically silent sporozoite and liver stages and preventing progression to the virulent blood stages. The leading preerythrocytic vaccine, RTS,S/AS01E (Mosquirix), entered implementation programs in 2019 and targets the major sporozoite surface antigen, circumsporozoite protein (CSP).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00165-21

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