Isolation and Characterization of a Novel Helicobacter Species, “ Helicobacter macacae ,” from Rhesus Monkeys with and without Chronic Idiopathic Colitis

Author:

Fox James G.1,Boutin Samuel R.1,Handt Laurence K.2,Taylor Nancy S.1,Xu Shilu1,Rickman Barry1,Marini Robert P.1,Dewhirst Floyd E.3,Paster Bruce J.3,Motzel Sherri2,Klein Hilton J.2

Affiliation:

1. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts

2. Merck Research Laboratories, Merck & Co., Inc., West Point, Pennsylvania

3. Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts

Abstract

ABSTRACT Chronic idiopathic colitis is a common clinical entity in young captive rhesus monkeys. Eight isolates, cultured from five monkeys in colony 1 with endemic diarrhea and three from colony 2 without diarrhea, were grown under microaerobic conditions on selective agar and were classified by full 16S rRNA sequence, biochemical, and phenotypic analysis as a novel helicobacter, “ Helicobacter macacae ” (proposed name). All eight strains of H. macacae had 99.5% identical 16S rRNA sequences.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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