A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic <i>fadB4</i> -Deficient <i>Mycobacterium tuberculosis</i> That Replicates Rapidly in Macrophages-Reference-Cited by-同舟云学术

A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic fadB4 -Deficient Mycobacterium tuberculosis That Replicates Rapidly in Macrophages

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Farzand Robeena¹,Haigh Richard D.¹,Monk Philip²,Haldar Pranabashis¹,Patel Hemu¹³,Pareek Manish¹³,Verma Raman¹³,Barer Michael R.¹,Woltmann Gerrit¹³,Ahyow Lauren⁴,Jagatia Heena¹,Decker Jonathan¹,Mukamolova Galina V.¹^ORCID,Cooper Andrea M.¹,Garton Natalie J.¹,O’Hare Helen M.¹^ORCID

Affiliation:

1. Leicester TB Research Group, Department of Respiratory Sciences, University of Leicester, Leicester, UK

2. Public Health England, Department of Health and Social Care in England, Government Agency, East Midlands, UK

3. University Hospitals Leicester NHS Trust, University of Leicester, Leicester, UK

4. National TB Unit, UK Health Security Agency, Government Agency, London, UK

Abstract

Tuberculosis (TB) killed 1.5 million people in 2020 and affects every country. The extent to which the natural genetic diversity of Mycobacterium tuberculosis influences disease manifestation at both the individual and epidemiological levels remains poorly understood.

Funder

European Commission

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02656-22

Reference58 articles.

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