Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3
Author:
Shuaib Yassir A.ORCID, Utpatel ChristianORCID, Kohl Thomas A., Barilar Ivan, Diricks MargoORCID, Ashraf Nadia, Wieler Lothar H., Kerubo Glennah, Mesfin Eyob A., Diallo Awa BaORCID, Al-Hajoj Sahal, Ndung’u Perpetua, Fitzgibbon Margaret M., Vaziri Farzam, Sintchenko Vitali, Martinez Elena, Viegas Sofia O., Zhou Yang, Azmy Aya, Al-Amry Khaled, Godreuil Sylvain, Varma-Basil Mandira, Narang Anshika, Ali Solomon, Beckert Patrick, Dreyer Viola, Kabwe MwilaORCID, Bates Matthew, Hoelscher MichaelORCID, Rachow Andrea, Gori AndreaORCID, Tekwu Emmanuel M., Sidze Larissa K., Jean-Paul Assam A., Beng Veronique P., Ntoumi Francine, Frank Matthias, Diallo Aissatou Gaye, Mboup SouleymaneORCID, Tessema BelayORCID, Beyene Dereje, Khan Sadiq N., Diel Roland, Supply Philip, Maurer Florian P.ORCID, Hoffmann Harald, Niemann Stefan, Merker Matthias
Abstract
Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-East and East Africa. This study provides a systematic understanding of the global diversity of L3 strains and reports phylogenetic variations that could inform clinical trials which evaluate the effectivity of new drugs/regimens or vaccine candidates.
Subject
Genetics (clinical),Genetics
Cited by
12 articles.
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