Heterologous Production of 1-Tuberculosinyladenosine in Mycobacterium kansasii Models Pathoevolution towards the Transcellular Lifestyle of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Heterologous Production of 1-Tuberculosinyladenosine in Mycobacterium kansasii Models Pathoevolution towards the Transcellular Lifestyle of Mycobacterium tuberculosis

Published:2020-10-27 Issue:5 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ghanem Marwan¹²³⁴,Dubé Jean-Yves¹²³^ORCID,Wang Joyce¹²³⁵,McIntosh Fiona²³,Houle Daniel²,Domenech Pilar²³,Reed Michael B.¹²³,Raman Sahadevan⁶,Buter Jeffrey⁷,Minnaard Adriaan J.⁷,Moody D. Branch⁶,Behr Marcel A.¹²³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, Canada

2. Infectious Disease and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Canada

3. McGill International TB Centre, Montreal, Canada

4. Faculty of Medicine, American University of Beirut, Beirut, Lebanon

5. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

6. Division of Rheumatology, Immunity and Inflammation, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

7. Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands

Abstract

This work sheds light on the role of the lipid 1-tuberculosinyladenosine in the evolution of an environmental ancestor to M. tuberculosis . On a larger scale, it reinforces the importance of horizontal gene transfer in bacterial evolution and examines novel models and methods to provide a better understanding of the subtle effects of individual M. tuberculosis -specific virulence factors in infection settings that are relevant to the pathogen.

Funder

Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02645-20

Reference40 articles.

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2. Attenuation ofMycobacterium tuberculosisFunctionally Disrupted in a Fatty Acyl–Coenzyme A Synthetase GenefadD5

3. Insights on the Emergence of Mycobacterium tuberculosis from the Analysis of Mycobacterium kansasii

4. Incidence and Clinical Implications of Isolation of Mycobacterium kansasii: Results of a 5-Year, Population-Based Study

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