Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies-Reference-Cited by-同舟云学术

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ng Weng M.¹^ORCID,Sahin Mehmet²,Krumm Stefanie A.³,Seow Jeffrey³,Zeltina Antra¹,Harlos Karl¹,Paesen Guido C.¹,Pinschewer Daniel D.²,Doores Katie J.³^ORCID,Bowden Thomas A.¹^ORCID

Affiliation:

1. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

2. Department of Biomedicine, Division of Experimental Virology, University of Basel, Basel, Switzerland

3. Kings College London, Department of Infectious Diseases, Guy’s Hospital, London, United Kingdom

Abstract

The GP1 subcomponent of the New World arenavirus GP is a primary target of the neutralizing antibody response, which has been shown to be effective in the prevention and treatment of infection. Here, we characterize the structural basis of the antibody-mediated immune response that arises from immunization of mice against Junín virus and Machupo virus, two rodent-borne zoonotic New World arenaviruses.

Funder

UKRI | Medical Research Council

Wellcome Trust

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02650-21

Reference69 articles.

1. Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1