Affiliation:
1. Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433
Abstract
ABSTRACT
VlsE, the variable surface antigen of
Borrelia burgdorferi
, contains a 26-amino-acid-long immunodominant invariable region, IR
6
. In the present study, three overlapping 14-mer peptides reproducing the sequence of IR
6
were used as peptide-based enzyme-linked immunosorbent assay antigens to map this invariable region in infected monkeys, mice, and human Lyme disease patients. Antibodies of the two primate species appeared to recognize IR
6
as a single antigenic determinant, while mouse antibodies recognized multiple epitopes within this region.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
30 articles.
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