Evolution of the <i>vls</i> Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes-Reference-Cited by-同舟云学术

Evolution of the vls Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Li Li¹^ORCID,Di Lia²^ORCID,Akther Saymon¹^ORCID,Zeglis Brian M.¹³⁴⁵^ORCID,Qiu Weigang¹²⁶⁷^ORCID

Affiliation:

1. Graduate Center, City University of New York, New York, New York, USA

2. Department of Biological Sciences, Hunter College, City University of New York, New York, New York, USA

3. Department of Chemistry, Hunter College, City University of New York, New York, New York, USA

4. Department of Radiology, Weill Cornell Medical College, New York, New York, USA

5. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

6. Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, USA

7. Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA

Abstract

Current diagnostic protocols of Lyme disease indirectly detect the presence of antibodies produced by the patient upon infection by the bacterial pathogen, not the pathogen itself. These diagnostic tests tend to underestimate early-stage bacterial infections before the patients develop robust immune responses.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01743-22

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