A Chlamydial Plasmid-Dependent Secretion System for the Delivery of Virulence Factors to the Host Cytosol-Reference-Cited by-同舟云学术

A Chlamydial Plasmid-Dependent Secretion System for the Delivery of Virulence Factors to the Host Cytosol

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lei Lei¹,Yang Chunfu¹,Patton Michael John¹,Smelkinson Margery²,Dorward David³,Ma Li¹,Karanovic Una¹,Firdous Saba¹,McClarty Grant⁴,Caldwell Harlan D.¹^ORCID

Affiliation:

1. Chlamydial Diseases Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

2. Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

3. Research Technologies Branch, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

4. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

The Chlamydia trachomatis plasmid regulates the expression and secretion of immune evasion virulence factors to the host cytosol by an unknown mechanism. In this study, we identified a novel plasmid gene protein 4 (Pgp4)-dependent secretion system.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01179-21

Reference39 articles.

1. The Global Burden of Trachoma: A Review

2. World Health Organization. 2016. WHO Guidelines for the Treatment of Chlamydia trachomatis. World Health Organization, Geneva, Switzerland.

3. Interaction of chlamydiae and host cells in vitro