Transient Mitochondria Dysfunction Confers Fungal Cross-Resistance against Phagocytic Killing and Fluconazole

Author:

Siscar-Lewin Sofía1,Gabaldón Toni234,Aldejohann Alexander M.5,Kurzai Oliver5ORCID,Hube Bernhard16ORCID,Brunke Sascha1ORCID

Affiliation:

1. Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, Jena, Germany

2. Barcelona Supercomputing Centre (BSC-CNS), Barcelona, Spain

3. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain

4. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

5. Institute for Hygiene and Microbiology, Julius-Maximilians-University, Würzburg, Germany

6. Institute of Microbiology, Friedrich Schiller University, Jena, Germany

Abstract

Candida glabrata is an opportunistic pathogen whose incidence has been increasing in the last 40 years. It has risen to become the most prominent non- Candida albicans Candida (NCAC) species to cause candidemia, constituting about one-third of isolates in the United States, and steadily increasing in European countries and in Australia.

Funder

FSU | Jena School for Microbial Communication, Friedrich-Schiller-Universität Jena

Friedrich-Schiller-Universität Jena

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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