Evaluation of outbreak persistence caused by multidrug-resistant and echinocandin-resistant Candida parapsilosis using multidimensional experimental and epidemiological approaches

Author:

Daneshnia Farnaz12,Floyd Daniel J.1,Ryan Adam P.3,Ghahfarokhy Pegah Mosharaf45,Ebadati Arefeh4,Jusuf Sebastian16,Munoz Julieta4,Jeffries Nathan Elias7,Elizabeth Yvanovich Emma7,Apostolopoulou Anna1,Perry Austin M.4,Lass-Flörl Cornelia8,Birinci Asuman9,Hilmioğlu-Polat Süleyha10,Ilkit Macit11,Butler Geraldine3,Nobile Clarissa J.45,Arastehfar Amir16,Mansour Michael K.16

Affiliation:

1. Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

2. Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, The Netherlands

3. School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland

4. Department of Molecular and Cell Biology, School of Natural Sciences, University of California – Merced, Merced, CA, USA

5. Health Sciences Research Institute, University of California – Merced, Merced, CA, USA

6. Department of Medicine, Harvard Medical School, Boston, MA, USA

7. Center for Regenerative Medicine, Boston, Massachusetts, USA

8. Medical University Innsbruck, Institute of Hygiene and Medical Microbiology, Innsbruck, Austria

9. Department of Medical Microbiology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye

10. Department of Medical Microbiology, Ege University Faculty of Medicine, Izmir, Türkiye

11. Division of Mycology, Faculty of Medicine, Çukurova University, Adana, Türkiye

Funder

National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases

NIH National Institute of General Medical Sciences

Publisher

Informa UK Limited

Reference37 articles.

1. Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap

2. Witt LS, Misas E, Farley MM, et al. 2885. Increased incidence of fluconazole-resistant Candida parapsilosis bloodstream infections in Atlanta, Georgia 2021. Open Forum Infect Dis; 2023;10(Suppl. 2):ofad500.162.

3. First Canadian report of transmission of fluconazole-resistant Candida parapsilosis within two hospital networks confirmed by genomic analysis;McTaggart LR;J Clin Microbiol,2023

4. Clonal Candidemia Outbreak by Candida parapsilosis Carrying Y132F in Turkey: Evolution of a Persisting Challenge

5. Environmental Clonal Spread of Azole-Resistant Candida parapsilosis with Erg11-Y132F mutation causing a large Candidemia outbreak in a Brazilian Cancer referral center;Thomaz DY;J fungi (Basel, Switzerland),2021

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