Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization-Reference-Cited by-同舟云学术

Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sun Xuan¹,Yang Jianming¹,Deng Xueqin¹,Wei Yuting¹,Wang Changying¹,Guo Yaxiu¹,Yang Huan¹^ORCID,Yang Liu¹,Miao Chunhui¹,Lv Junqiang¹,Xiao Yawen¹,Zhang Hong¹,Yao Zhi¹²,Wang Quan¹²^ORCID

Affiliation:

1. Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Urology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

2. The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, China

Abstract

CNF1 is a key toxin secreted by UPEC, which induces inflammation during UPEC infections. CNF1 is well known to activate Rho GTPases to disturb host cell signaling pathways.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01147-22

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