Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs

Author:

Mohring Franziska1,van Schalkwyk Donelly A.1,Henrici Ryan C.2,Blasco Benjamin3,Leroy Didier3,Sutherland Colin J.14ORCID,Moon Robert W.1ORCID

Affiliation:

1. Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

2. Center for Global Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

3. Medicines for Malaria Venture, Geneva, Switzerland

4. UK Health Security Agency Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

Effective drugs are vital to minimize the illness and death caused by malaria. Development of new drugs becomes ever more urgent as drug resistance emerges.

Funder

Medicines for Malaria Venture

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference58 articles.

1. World Health Organization. 2021. World malaria report 2021. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021.

2. World Health Organization. 2020. World malaria report 2020: 20 years of global progress and challenges. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2020.

3. Deaths From Plasmodium knowlesi Malaria: Case Series and Systematic Review

4. World Health Organization. 2015. Guidelines for the treatment of malaria, 3rd ed. World Health Organization, Geneva, Switzerland.

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