Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

Author:

Ashton Trent D.12ORCID,Dans Madeline G.12,Favuzza Paola12,Ngo Anna12,Lehane Adele M.3ORCID,Zhang Xinxin3,Qiu Deyun3,Chandra Maity Bikash4,De Nirupam4,Schindler Kyra A.5,Yeo Tomas5,Park Heekuk5,Uhlemann Anne-Catrin5ORCID,Churchyard Alisje6,Baum Jake67,Fidock David A.58,Jarman Kate E.12,Lowes Kym N.12,Baud Delphine9,Brand Stephen9,Jackson Paul F.10,Cowman Alan F.12,Sleebs Brad E.12ORCID

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia

2. Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia

3. Research School of Biology, Australian National University, Canberra 2601, Australia

4. TCG Lifesciences Pvt. Ltd., Saltlake Sec-V, Kolkata 700091, West Bengal, India

5. Department of Microbiology & Immunology, Columbia University, Irving Medical Center, New York, New York 10032, United States

6. Department of Life Sciences, Imperial College London, South Kensington SW7 2AZ U.K.

7. School of Biomedical Sciences, University of New South Wales, Sydney 2031, Australia

8. Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University, Irving Medical Center, New York, New York 10032, United States

9. Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, 1215 Geneva, Switzerland

10. Global Public Health, Janssen R&D LLC, La Jolla, California 92121, United States

Funder

National Health and Medical Research Council

Wellcome

Medicines for Malaria Venture

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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