The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase-Reference-Cited by-同舟云学术

The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Alhammad Yousef M. O.¹,Kashipathy Maithri M.²,Roy Anuradha³,Gagné Jean-Philippe⁴⁵,McDonald Peter³,Gao Philip⁶,Nonfoux Louis⁴⁵,Battaile Kevin P.⁷,Johnson David K.⁸,Holmstrom Erik D.¹,Poirier Guy G.⁴⁵,Lovell Scott²,Fehr Anthony R.¹^ORCID

Affiliation:

1. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA

2. Protein Structure Laboratory, University of Kansas, Lawrence, Kansas, USA

3. High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, USA

4. Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Québec City, Quebec, Canada

5. Oncology Division, CHU de Québec Research Center, Québec City, Quebec, Canada

6. Protein Production Group, University of Kansas, Lawrence, Kansas, USA

7. NYX, New York Structural Biology Center, Upton, New York, USA

8. Molecular Graphics and Modeling Laboratory and the Computational Chemical Biology Core, University of Kansas, Lawrence, Kansas, USA

Abstract

SARS-CoV-2 has recently emerged into the human population and has led to a worldwide pandemic of COVID-19 that has caused more than 1.2 million deaths worldwide. With no currently approved treatments, novel therapeutic strategies are desperately needed.

Funder

HHS | National Institutes of Health

U.S. Department of Energy

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01969-20

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1. A pneumonia outbreak associated with a new coronavirus of probable bat origin