Ultradeep HIV-1 Proviral Envelope Sequencing Reveals Complex Population Structure within and between Brain and Splenic Tissues-Reference-Cited by-同舟云学术

Ultradeep HIV-1 Proviral Envelope Sequencing Reveals Complex Population Structure within and between Brain and Splenic Tissues

Published:2021-11-09 Issue:23 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rose Rebecca¹^ORCID,Gonzalez-Perez Maria Paz²,Nolan David J.¹,Cross Sissy¹,Lamers Susanna L.¹,Luzuriaga Katherine²^ORCID

Affiliation:

1. BioInfoExperts, LLC, Thibodaux, Louisiana, USA

2. Program in Molecular Medicine, T.H. Chan School of Medicine at UMass Medical School, Worcester, Massachusetts, USA

Abstract

Understanding the evolution of HIV-1 in the brain compared to other tissues is important for improving treatment strategies for individuals with HIV-associated neurological disorders (HAND). We utilized high-throughput sequencing technology to generate thousands of full-length env sequences from paired brain and spleen samples from eight individuals with/without HAND.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01202-21

Reference30 articles.

1. Neurological Complications of HIV Infection

2. Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications

3. HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues