Distinct HIV-1 Population Structure across Meningeal and Peripheral T Cells and Macrophage Lineage Cells-Reference-Cited by-同舟云学术

Distinct HIV-1 Population Structure across Meningeal and Peripheral T Cells and Macrophage Lineage Cells

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Rose Rebecca¹,Gonzalez-Perez Maria Paz²,Nolan David¹,Ganta Krishna Kumar²,LaFleur Tessa¹,Cross Sissy¹,Brody Robin²,Lamers Susanna L.¹,Luzuriaga Katherine²^ORCID

Affiliation:

1. BioInfoExperts, LLC, Thibodaux, Louisiana, USA

2. UMass Chan Medical School, Worcester, Massachusetts, USA

Abstract

Different cell types and/or tissues may serve as a reservoir for HIV-1 during ART-induced viral suppression. We compared proviral pol and env sequences from CD3 + T cells and CD14 + macrophage lineage cells from brain and nonbrain tissues from two virally suppressed individuals. We found strong evidence of viral population structure among cells/tissues, which may result from distinct selective pressures across cell types and anatomic sites.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02508-22

Reference64 articles.

1. T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells

2. Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic function

3. Healthy HIV-1-Infected Individuals on Highly Active Antiretroviral Therapy Harbor HIV-1 in Their Alveolar Macrophages

4. Gastrointestinal Tract and the Mucosal Macrophage Reservoir in HIV Infection

5. HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

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