Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System-Reference-Cited by-同舟云学术

Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System

Published:2022-08-16 Issue:8 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Kaplan Mohammed¹,Oikonomou Catherine M.¹,Wood Cecily R.²,Chreifi Georges¹,Ghosal Debnath³,Dobro Megan J.⁴,Yao Qing¹,Pal Ritesh Ranjan⁵⁶,Baidya Amit K.⁵⁷,Liu Yuxi¹,Maggi Stefano¹,McDowall Alasdair W.¹,Ben-Yehuda Sigal⁵,Rosenshine Ilan⁵,Briegel Ariane⁸^ORCID,Beeby Morgan⁹,Chang Yi-Wei¹⁰,Shaffer Carrie L.²¹¹¹²,Jensen Grant J.¹¹³^ORCID

Affiliation:

1. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA

2. Department of Veterinary Sciences, University of Kentucky College of Agriculture, Lexington, Kentucky, USA

3. Division of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia

4. Hampshire College, Amherst, Massachusetts, USA

5. Department of Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

6. School of Biological Sciences, Indian Association for the Cultivation of Science, Kolkata, West Bengal, India

7. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, India

8. Leiden University, Institute of Biology, Leiden, The Netherlands

9. Department of Life Sciences, Imperial College London, South Kensington Campus, London, United Kingdom

10. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

11. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA

12. Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA

13. Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA

Abstract

The type III secretion system (T3SS) is a fascinating suite of proteins involved in building diverse macromolecular systems, including the bacterial flagellar motility machine, the injectisome machinery that bacteria use to inject effector proteins into host cells, and probably membrane nanotubes which connect bacterial cells. Here, we accidentally discovered a novel inner membrane-associated complex related to the flagellar T3SS.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00144-22

Reference38 articles.

1. In Situ Imaging and Structure Determination of Biomolecular Complexes Using Electron Cryo-Tomography

2. In Situ Imaging and Structure Determination of Bacterial Toxin Delivery Systems Using Electron Cryotomography

3. Uncharacterized Bacterial Structures Revealed by Electron Cryotomography