Affiliation:
1. Biochemical Research Laboratory, The Dow Chemical Company, Midland, Michigan
Abstract
Neely, W. Brock
(The Dow Chemical Co., Midland, Mich.). Action of formaldehyde on microorganisms. III. Bactericidal action of sublethal concentrations of formaldehyde on
Aerobacter aerogenes
. J. Bacteriol.
86:
445–448. 1963.—Bacteriostatic concentrations of formaldehyde were found to be bactericidal during the initial growth period. This bactericidal activity was due to the primary induction of unbalanced growth by formaldehyde. The subsequent formation of 1,3-thiazane-4-carboxylic acid prevented the synthesis of methionine. This dual activity of formaldehyde resulted in an inhibition of both nuclear and cytoplasmic syntheses, and created the normal bacteriostatic condition that has been observed before with sublethal concentrations of formaldehyde.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
21 articles.
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