Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus-Reference-Cited by-同舟云学术

Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus

Published:2017-03-15 Issue:6 Volume:91 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Reis Ana Luisa¹,Netherton Chris¹,Dixon Linda K.¹

Affiliation:

1. The Pirbright Institute, Ash Road Pirbright, Woking, Surrey, United Kingdom

Abstract

ABSTRACT African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of the Asfarviridae family. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways.

Funder

RCUK | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02338-16

Reference21 articles.

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2. African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes

3. Repair of base damage and genome maintenance in the nucleo-cytoplasmic large DNA viruses