Chromosomal Integration and Location on IncT Plasmids of theblaCTX-M-2Gene in Proteus mirabilis Clinical Isolates

Abstract

ABSTRACTAnalysis of five CTX-M-2-producingProteus mirabilisisolates in Japan demonstrated thatblaCTX-M-2was located on the chromosome in four isolates and on IncT plasmids in three isolates, including two isolates that also carried the gene on the chromosome. In all four isolates with chromosomalblaCTX-M-2, ISEcp1was responsible for the integration of the gene into the chromosome. Three different sites in theP. mirabilisgenomic sequence were utilized as integration sites.