Effects of Ethambutol on Phospholipid Metabolism in Mycobacterium smegmatis-Reference-Cited by-同舟云学术

Effects of Ethambutol on Phospholipid Metabolism in Mycobacterium smegmatis

Published:1981-02 Issue:2 Volume:19 Page:346-348
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kilburn James O.¹,Takayama Kuni²³,Armstrong Emma Lee²,Greenberg Joseph¹

Affiliation:

1. Bureau of Laboratories, Center for Disease Control, Atlanta, Georgia 30333

2. Mycobacteriology Laboratory, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705

3. Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin 53706

Abstract

Soon after Mycobacterium smegmatis was exposed to ethambutol, the synthesis of cardiolipin and phosphatidylinositol dimannoside declined. The synthesis of phosphatidylethanolamine continued, but the drug caused this phospholipid to leak out of the cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.19.2.346

Reference5 articles.

1. Beggs W. H. 1979. Ethambutol p. 43-66. In F. E. Hahn (ed.) Antibiotics mechanism of action of antibacterial agents vol. 5 part 1. Springer-Verlag New York Inc. New York.

2. A simple, specific spray for the detection of phospholipids on thin-layer chromatograms;Dittmer J. C.;J. Lipid Res.,1964

3. Secretion of lipids induced by inhibition of peptidoglycan synthesis in streptococci;Horne D.;J. Bacteriol.,1977

4. Effect of ethambutol on the viable cell count in Mycobacterium smegmatis;Kilburn J. O.;Antimicrob. Agents Chemother.,1977

5. Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis;Takayama K.;Antimicrob. Agents Chemother.,1979

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