Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis-Reference-Cited by-同舟云学术

Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis

Published:1979-08 Issue:2 Volume:16 Page:240-242
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Takayama Kuni¹,Armstrong Emma L.¹,Kunugi Keith A.¹,Kilburn James O.²

Affiliation:

1. Tuberculosis Research Laboratory, William S. Middleton Memorial Veterans Medical Center, Madison, Wisconsin 53705; Institute for Enzyme Research, University of Wisconsin, Madison, Wisconsin 53706;

2. Bureau of Laboratories, Center for Disease Control, Atlanta, Georgia 30333

Abstract

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis . Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive inhibition was involved.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.16.2.240

Reference13 articles.

1. Stereochimie des acides mycoliques;Asselineau C.;Bull. Soc. Chim. Fr., p.,1970

2. Nonspecific ionic inhibition of ethambutol binding by Mycobacterium smegmatis;Beggs W. IL;Antimicrob. Agents Chemother.,1973

3. Effect of ethambutol on nucleic acid metabolism in Mycobacterium smegmatis and its reversal by polyamines and divalent cations;Forbes M.;J. Bacteriol.,1965

4. Myambutol: chemistry, pharmacology, and toxicity;Kanther R.;Antibiot. Chemother.,1970

5. The in vitro activity of ethambutol (dextro-2,2'-[ethylenediimino]-di-1-butanol) against tubercle bacilli and other microorganisms;Karlson A. G.;Am. Rev. Respir. Dis.,1961

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