Affiliation:
1. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Abstract
Measles virus (MeV) may persist in the brain, causing incurable subacute sclerosing panencephalitis (SSPE). Because neurons, the main target in SSPE, do not express receptors for wild-type (WT) MeV, how MeV propagates in the brain is a key question for the disease. Recent studies have demonstrated that specific substitutions in the MeV fusion (F) protein are critical for neuropathogenicity. Here, we show that weak
cis
and
trans
interactions of the MeV attachment protein with receptors that are not sufficient to trigger the WT MeV F protein can trigger the mutant F proteins from neuropathogenic MeV isolates. Our study not only provides an important clue to understand MeV neuropathogenicity but also reveals a novel viral strategy to expand cell tropism.
Funder
Kyushu University
Japan Agency for Medical Research and Development
MEXT | Japan Society for the Promotion of Science
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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