Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein

Author:

Takemoto Ryuichi12,Hirai Yuichi1,Watanabe Shumpei3,Harada Hidetaka1,Suzuki Tateki4,Hashiguchi Takao4ORCID,Yanagi Yusuke5ORCID,Shirogane Yuta1ORCID

Affiliation:

1. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

2. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

3. Department of Microbiology, Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan

4. Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University

5. National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan

Abstract

Measles is an acute febrile illness with skin rash. Despite the availability of highly effective vaccines, measles is still an important cause of childhood morbidity and mortality in many countries.

Funder

MEXT | Japan Society for the Promotion of Science

Takeda Science Foundation

The Chemo-Sero-Therapeutic Research Institute

Uehara Memorial Foundation

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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