Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD- scid IL2R γ null Mice Engrafted with Human Erythrocytes-Reference-Cited by-同舟云学术

Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD- scid IL2R γ null Mice Engrafted with Human Erythrocytes

Published:2009-10 Issue:10 Volume:53 Page:4533-4536
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jiménez-Díaz María Belén¹,Mulet Teresa¹,Viera Sara¹,Gómez Vanessa¹,Garuti Helen¹,Ibáñez Javier¹,Alvarez-Doval Angela¹,Shultz Leonard D.²,Martínez Antonio¹,Gargallo-Viola Domingo¹,Angulo-Barturen Iñigo¹

Affiliation:

1. ID CEDD Diseases of the Developing World, GlaxoSmithKline, c/Severo Ochoa 2, 28760, Tres Cantos, Spain

2. The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609

Abstract

ABSTRACT Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD- scid IL2Rγ null mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD- scid β2microglobulin null mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc 1 .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00519-09

Reference14 articles.

1. Angulo-Barturen, I., M. B. Jiménez-Díaz, T. Mulet, J. Rullas, E. Herreros, S. Ferrer, E. Jiménez, A. Mendoza, J. Regadera, P. J. Rosenthal, I. Bathurst, D. L. Pompliano, F. Gómez de las Heras, and D. Gargallo-Viola. 2008. A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS One3:e2252.

2. Badell, E., V. Pasquetto, P. Druilhe, and N. Van Rooijen. 1995. A mouse model for human malaria erythrocytic stages. Parasitol. Today11:235-237.

3. Bloland P. P. Ringwald and R. W. Snow. 2003. Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria. World Health Organization Geneva Switzerland. http://www.who.int/malaria/docs/ProtocolWHO.pdf .

4. Christianson, S. W., D. L. Greiner, R. A. Hesselton, J. H. Leif, E. J. Wagar, I. B. Schweitzer, T. V. Rajan, B. Gott, D. C. Roopenian, and L. D. Shultz. 1997. Enhanced human CD4+ T cell engraftment in β2-microglobulin-deficient NOD-scid mice. J. Immunol.158:3578-3586.

5. Coslédan, F., L. Fraisse, A. Pellet, F. O. Guillou, B. Mordmüller, P. G. Kremsner, A. Moreno, D. Mazier, J.-P. Maffrand, and B. Meunier. 2008. Selection of a trioxaquine as an antimalarial drug candidate. Proc. Natl. Acad. Sci. USA105:17579-17584.

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