Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors-Reference-Cited by-同舟云学术

Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors

Published:2007-07 Issue:7 Volume:51 Page:2631-2635
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hudson Debra L.¹,Layton Abigail N.¹,Field Terry R.¹,Bowen Alison J.¹,Wolf-Watz Hans²,Elofsson Mikael³,Stevens Mark P.¹,Galyov Edouard E.¹

Affiliation:

1. Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom

2. Department of Molecular Biology

3. Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden

Abstract

ABSTRACT Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01492-06

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